Evaluation Of Antiulcer Activity Of Alcoholic Extract Of Garuga pinnata Roxb. Leaves In Experimental Animal Models

Ulcers are the most common form of GI disorder that is often caused by either inflammation or infection that certainly affected 10% of the population at risk. Among all types of ulcers, peptic ulcer is the more catastrophic one. This point made an exemption objective to conduct an investigation for antiulcer activity of alcoholic extract of Garuga pinnata leaves in rats. Acute gastric lesions in rats was provoked by pylorus ligation, cold strain stress and indomethacin induction models. The experimental protocol assigned the animals (male albino wistar rats) into five groups of five animals each. The selected dose i.e. (100 and 200mg/kg p.o) of the Garuga pinnata leaf extract (GPLE) was administered to group IV and group V which was compared and scrutinized with the other groups. The anti-ulcer activity was evaluated by measuring the clinical parameters such as ulcer index, gastric content and total acidity of gastric fluid, pH value, gastric volume and antioxidant parameters such as lipid peroxidation level and glutathione parameters. The resultant data showed the noteworthy effect on ulcer induced by different ulcer induced models. In conclusion, the outcome demonstrated the antiulcer activity of GPLE which may be exhibited due to the presence of tannins and flavanoids.